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Mark Slifstein, PhD

Mark
Professor of Psychiatry
Director, PET Research Core

Office:        631-638-0065

mark.slifstein@stonybrookmedicine.edu

Department of Psychiatry        

Education

PhD, Mathematics, New York University, 1999
MS, Mathematics, New York University, 1995
BA, Mathematics, New York University, 1993

Employment/Experience

1998 - 2000 Research Scientist, Research Foundation for Mental Hygiene at the New York State Psychiatric Institute
2001 - 2008 Assistant Professor of Clinical Neuroscience, Dept. of Psychiatry, Columbia College of Physicians and Surgeons and New York State Psychiatric Institute (Research Scientist VI)
2004  Director, Brain Imaging Core, Silvio O Conte Center for Schizophrenia Research
2005 Director, Data Analysis, Division of Translational Imaging, New York State Psychiatric Institute
2008 Associate Professor, Neurobiology (In Psychiatry), Dept. of Psychiatry, Columbia College of Physicians and Surgeons and New York State Psychiatric Institute (Research Scientist VI)
2015 – 2016 Interim Director, MRI Research Unit, New York State Psychiatric Institute
2016 Professor, Department of Psychiatry, Stony Brook University
2016 Director, PET Research Core, Stony Brook University
Advisory Boards and Activities/Editorial Boards
2008 Member, Scientific Advisory Board, Program Committee, Neuroreceptor Mapping and BrainPET
2009 Editorial Board, Neuropsychopharmacology
2013 Editorial Board, Journal of Cerebral Blood Flow and Metabolism
2013 Editorial Board, Neuroscience-Net (NSNJ)

              

Training

Mark Slifstein attended New York University where, as an undergraduate, he was elected to Phi Beta Kappa and graduated summa cum laude with a BA in mathematics, followed by an MS and PhD, also in mathematics. He began his career as a research scientist at the New York State Psychiatric Institute (NYSPI) and Columbia University College of Physicians and Surgeons, eventually becoming Associate Professor of Neurobiology in the Department of Psychiatry. During this time, he also served as Director of Data Analysis, Division of Translational Imaging Director of the MRI Research Unit at NYSPI and Director of the Brain Imaging Core in the Silvio O. Conte Center for Schizophrenia Research.  Dr. Slifstein joined Stony Brook Medicine in 2016, as Professor, Department of Psychiatry, Stony Brook University School of Medicine, and Director of the PET Research Core.  The PET Research Core oversees and facilitates all aspects of PET research for Stony Brook investigators, including experimental design, data acquisition, radiotracer development and production and data analysis. 

Honors/Awards

Graduated summa cum laude, B.A., 1993

Elected to Phi Beta Kappa , 1993

Research

Dr. Slifstein’s main research interests include pharmacokinetics and pharmacokinetic analysis in PET imaging, PET and SPECT neuroimaging, multimodal imaging, the neurobiology of schizophrenia, dopaminergic neurotransmission and dopamine imaging in psychiatry. Other areas of interest include data reduction methods in imaging and image reconstruction methods.

Representative Publications

  • Slifstein, M. and Laruelle, M., Effects of Statistical Noise on Graphical Analysis of PET Neuroreceptor Studies. J. Nucl. Med., 2000. 41(12): p. 2083-2088.
  • Slifstein, M. and Laruelle, M., Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers. Nucl. Med. Bio., 2001. 28: p. 595-608.
  • Laruelle, M., Slifstein, M., and Huang, Y., Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography. Mol Imaging Biol., 2003. 5(6): p. 363-375.
  • Slifstein, M., Narendran, R., Hwang, D.R., Sudo, Y., Talbot, P.S., Huang, Y.Y., and Laruelle, M., Effect of amphetamine on [F-18]fallypride in vivo binding to D-2 receptors in striatal and extrastriatal regions of the primate brain: Single bolus and bolus plus constant infusion studies. Synapse, 2004. 54(1): p. 46-63.
  • Ekelund, J., Slifstein, M., Narendran, R., Guillin, O., Belani, H., Guo, N.N., Hwang, Y., Hwang, D.R., Abi-Dargham, A., and Laruelle, M., In vivo DA D-1 receptor selectivity of NNC 112 and SCH 23390. Molecular Imaging and Biology, 2007. 9(3): p. 117-125.
  • Slifstein, M., Revisiting an old issue: The discrepancy between tissue ratio-derived binding parameters and kinetic modeling-derived parameters after a bolus of the serotonin transporter radioligand I-123-ADAM. Journal of Nuclear Medicine, 2008. 49(2): p. 176-178.
  • Kegeles, L.S., Slifstein, M., Frankle, W.G., Xu, X.Y., Hackett, E., Bae, S.A., Gonzales, R., Kim, J.H., Alvarez, B., Gil, R., Laruelle, M., and Abi-Dargham, A., Dose-Occupancy Study of Striatal and Extrastriatal Dopamine D-2 Receptors by Aripiprazole in Schizophrenia with PET and [F-18] Fallypride. Neuropsychopharmacology, 2008. 33(13): p. 3111-3125.
  • Rabiner, E., Slifstein, M., Nobrega, J., Plisson, C., Huiban, M., Raymond, R., Diwan, M., Wilson, A.A., McCormick, P., Gentile, G., Gunn, R.N., and Laruelle, M., In vivo quantification of regional dopamine-D3 receptor binding potential of (+)PHNO: studies in non-hman primates and transgenic mice. Synapse, 2009. 63: p. 782-793.
  • Ridler, K., Plisson, C., Rabiner, E.A., Gunn, R.N., Easwaramoorthy, B., Abi-Dargham, A., Laruelle, M., and Slifstein, M., Characterization of in vivo pharmacological properties and sensitivity to endogenous serotonin of [11C] P943: a positron emission tpmography study in papio anubis. Synapse, 2011. 65(11): p. 1119-1127.
  • Abi-Dargham, A., Xu, X., Thompson, J.L., Gil, R., Kegeles, L.S., Urban, N., Narendran, R., Hwang, D.R., Laruelle, M., and Slifstein, M., Increased prefrontal cortical D(1) receptors in drug naive patients with schizophrenia: a PET study with [(1)(1)C]NNC112. Journal of psychopharmacology, 2012. 26(6): p. 794-805.
  • Slifstein, M., van de Giessen, E., Van Snellenberg, J., Thompson, J.L., Narendran, R., Gil, R., Hackett, E., Girgis, R., Ojeil, N., Moore, H., D'Souza, D., Malison, R.T., Huang, Y., Lim, K., Nabulsi, N., Carson, R.E., Lieberman, J.A., and Abi-Dargham, A., Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study. JAMA Psychiatry, 2015. 72(4): p. 316-24.
  • Gunn, R.N., Slifstein, M., Searle, G.E., and Price, J.C., Quantitative imaging of protein targets in the human brain with PET. Phys Med Biol, 2015. 60(22): p. R363-411.

 PubMed Linked Publications