Parkinson’s disease (PD) and multiple system atrophy (MSA) are associated with the misfolding, accumulation, and aggregation of alpha-synuclein protein. This study tested for detectable differences in misfolded alpha-synuclein aggregates in participants with PD, MSA, Rapid Eye Movement Sleep Behavior Disorder (RBD) and non-parkinsonian controls in different biofluids including cerebrospinal fluid, blood, saliva, and urine.
